Figure 4

Meningeal inflammation is topographically associated with cortical demyelination in early MS (autopsy tissue from patients with acute MS). (A) Subpial lesion overlaid by a perivascular meningeal inflammatory infiltrate (PLP, scale bar = 500 μm); (B) Higher magnification of (A) (PLP, scale bar = 250 μm); (C) Higher magnification of the perivascular meningeal infiltrate (HE, scale bar = 50 μm); (D) Intracortical lesion overlaid by perivascular meningeal inflammation (PLP, scale bar = 250 μm); (E) Higher magnification of the perivascular meningeal infiltrate (PLP, scale bar = 50 μm); (F) Macrophages are components of the perivascular meningeal infiltrate (KiM1P, scale bar = 100 μm); (G) Large subpial lesion underlying meningeal inflammation (PLP, scale bar = 500 μm); (H) Higher magnification of the meningeal inflammation (PLP, scale bar = 100 μm); (I) Myelin-laden macrophages are found in the meninges of patients with acute MS (PLP, scale bar = 20 μm).