Figure 3
From: ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective
Effect of antimycin A, a compound known to be toxic to mitochondria, and chlorpromazine on parent HepG2 cells (MITO-R, blue) and a HepG2 cell line that has been developed to become sensitive to mitochondrial toxicants (MITO-S, red). Left-hand side, antimycin A; right-hand side, chlorpromazine.