Fig. 5

The association between leading risk factors and incident Alzheimer’s disease stratified by APOE4. APOE4, apolipoprotein E ε4; CAIDE, Cardiovascular Risk Factors, Aging, and Incidence of Dementia; HDL-C, high-density lipoprotein cholesterol. Cox proportional hazards regression models were used to test whether APOE4 modified associations between leading risk factors and incident Alzheimer’s disease. Multivariable model was adjusted for age, sex, education, household income, BMI, smoking, physical activity, diet score, alcohol consumption, and sleep duration