Fig. 2
Dysregulation of mitochondrion-associated and mitochondrion-associated genes in individuals in the DPN group. Volcano plots showing DEGs in tissues from DPN patients vs. HC participants: A dysregulated mitochondrion-associated genes in GSE185011 dataset; B dysregulated PN-associated genes in GSE185011 dataset; C dysregulated mitochondrion-associated genes in GSE95849 dataset; D dysregulated PND-associated genes in GSE95849 dataset. The size of each data point is proportional to the -log10(FDR adjusted p-value), and log2(fold change) values are color-coded according to the provided scale. E Omic circos diagram displaying the position and expression levels of the shared differentially mitochondrion-associated and PND-associated genes mapping to their position on the chromosome circular track (the outer track). The two heatmap track display the expression level of the 19 shared differentially mitochondrion-associated genes and PND-associated genes in DPN patients compared to HC participants in GSE185011 (the first heatmap track) and GSE95849 (the second heatmap track) datasets, with heatmap color representing expression levels