Effect of heart rate on poor outcome in stroke patients treated with intra-arterial thrombectomy

BMC Neurology

Table 3 The association between heart rate measures and 3-month worse functional outcome in MT-treated acute ischemic stroke patients

Heart rate measures	Unadjusted			Model 1*			Model 2†
Heart rate measures	OR (95% Cl)	P value	P for trend	OR (95% Cl)	P value	P for trend	OR (95% Cl)	P value	P for trend
72-hr mean heart rate			< 0.001			< 0.001			0.005
Tertile 1 (< 73.6 bpm)	Reference			Reference			Reference
Tertile2 (73.6–86.7 bpm)	1.42 (0.77–2.61)	0.26		1.48 (0.80–2.74)	0.22		1.17 (0.61–2.24)	0.63
Tertile3 (> 86.7 bpm)	4.38 (2.30–8.37)	< 0.001		4.29 (2.23–8.26)	< 0.001		2.73 (1.36–5.46)	0.005
per 10-bpm increase	1.59 (1.32–1.91)	< 0.001		1.56 (1.30–1.88)	< 0.001		1.35 (1.11–1.64)	0.002
72-hr heart rate SD			< 0.001			< 0.001			< 0.001
Tertile 1 (< 8.3 unit)	Reference			Reference			Reference
Tertile2 (8.3–12.1 unit)	3.28 (1.74–6.17)	< 0.001		3.47 (1.83–6.56)	< 0.001		2.48 (1.26–4.85)	0.008
Tertile 3 (> 12.1 unit)	4.86 (2.54–9.30)	< 0.001		5.30 (2.74–10.25)	< 0.001		3.52(1.76–7.03)	< 0.001
per 5-unit increase	1.47 (1.19–1.82)	< 0.001		1.46 (1.18–1.81)	< 0.001		1.27 (1.05–1.53)	0.01
72-hr heart rate CV			0.02			0.007			0.049
Tertile 1 (< 10.8 unit)	Reference			Reference			Reference
Tertile 2 (10.8–14.5 unit)	1.59 (0.86–2.94)	0.14		1.67 (0.90–3.11)	0.10		1.53 (0.81–2.90)	0.19
Tertile 3 (> 14.5 unit)	2.11 (1.13–3.93)	0.02		2.36 (1.26–4.43)	0.008		1.94 (0.99–3.80)	0.05
per 5-unit increase	1.25 (1.04–1.50)	0.02		1.25 (1.04–1.50)	0.02		1.19 (1.02–1.40)	0.03

*Model 1: Adjusted for age, sex;
†Model 2: Adjusted age, sex, medical history of hypertension, admission NIHSS score, preprocedural collateral status (ASITN/SIR 2/3), and postprocedural recanalization (mTICI score 2b/3). ASITN/SIR indicates the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology; bpm, beat per minute; CI, confidence interval; heart rate SD, heart rate standard deviation; heart rate CV, heart rate coefficient of variation; HR, hazard ratio; MT, mechanical thrombectomy; mTICI, modified Thrombolysis in Cerebral Ischemia; NIHSS, National Institutes of Health Stroke Scale

ISSN: 1471-2377