Diagnosis of human angiostrongyliasis in a case of hydrocephalus using next-generation sequencing: a case report and literature review

Table 1 Summary of CSF mNGS features in cases of A. cantonensis infection

Study	Sex/age	CSF Eosinophilia (%)	ELISA	SSRN reads	Coverage(%)	Other Microbe	Confirmatory data
Liu et al. 2022 [11]	M/8	NA	+	22	0.0079	No	PCR, antibody
Feng et al. 2020 [9]	M/27	67	+	13,492	0.3115	Yes	qPCR, antibody
Zou et al. 2020 [21]	M/43	80	-	3805	0.0645	NA	Clinical
Xie et al. 2019 [10]	M/2	68.91	+	3204	0.0786	No	third-stage larva was found in ocular
	M/3	33	-	892	0.0345	No	Clinical
Zhang et al. 2019 [12]	M/59	21.9	+	17,202	NA	Yes	Antibody, Clinical
This study	M/13	NA	NA	4451	0.0892	Yes	Clinical

SSRN species-specific read number, NA not available, ELISA enzyme-linked immunosorbent assay: The results of Elisa revealed that both the serum and the CSF were positive forantibodies against A. cantonensis, Clinical evidence: patient’s history, clinical presentation, imaging finding, routine laboratory CSF results and response to antibiotic treatment. PCR polymerase chain reaction, qPCR quantitative polymerase chain reaction

ISSN: 1471-2377