Skip to main content

Table 1 Data from Table 2 of the article by Malaty et al. (2022) [1] with our own calculations of the accuracy measures. It should be noted that we inverted the columns and rows of the cross table, so that “yes” and “positive” appear on the left and top of the cross table, respectively. In the cross table, the letters A, B, C and D are shown to indicate the calculation steps used to calculate the diagnostic measures

From: Comment on “Does the 5-2-1 criteria identify patients with advanced Parkinson’s disease? Real-world screening accuracy and burden of 5-2-1-positive patients in 7 countries”

  

advanced PD

Malaty et al.

       Our calculations of accuracy measures

5-2-1 screening criteria

 

yes

no

CCR

     (A+D)/(A+B+C+D)

SENSA/(A+C)

SPECD/(C+D)

PPVA/(A+B)

pos

552A

994B

1546

88.1%

75.7%

78.6%

75.2%

35.7%

neg

150C

3018D

3168

702

4012

4714

≥ 2 h off-time/day

 

yes

no

88.4%

80.5%

70.4%

82.2%

40.9%

pos

494A

713B

1207

neg

208C

3299D

3507

702

4012

4714

≥ 1 h troublesome dyskinesia/day

 

yes

no

87.1%

86.0%

15.8%

98.3%

62.0%

pos

111A

68B

179

neg

591C

3944D

4535

702

4012

4714

≥ 5 doses of oral levodopa/day

 

yes

no

87.1%

80.4%

41.2%

87.3%

36.1%

pos

289A

511B

800

neg

413C

3501D

3914

702

4012

4714

  1. Abbreviations: CCR = correct classification rate, SENS = sensitivity, SPEC = specificity, PPV = positive predictive value, pos = positive, neg = negative, ∑ = row/column total.