Comment on “Does the 5-2-1 criteria identify patients with advanced Parkinson’s disease? Real-world screening accuracy and burden of 5-2-1-positive patients in 7 countries”

Table 2 Cross table based on the accuracy measures as provided in the response by Antonini et al. [6]. The calculation steps for creating the cross table of the adjusted model are described at the bottom of the table

		advanced PD			CCR	SENS	SPEC	PPV	NPV
adjusted regression model of 5-2-1 criteria		yes	no	∑	88.1%	41.9%	96.2%	65.9%	90.4%
	pos	294†	152§	446
	neg	408¥	3860*	4268
	∑	702	4012	4714
unadjusted 5-2-1 screening criteria		yes	no	∑	75.7%	78.6%	75.2%	35.7%	95.3%
	pos	552	994	1546
	neg	150	3018	3168
	∑	702	4012	4714

Abbreviations: CCR = correct classification rate, SENS = sensitivity, SPEC = specificity, PPV = positive predictive value, NPV = negative predictive value, pos = positive, neg = negative, ∑ = row/column total.
† the number of true positives was calculated as follows: sensitivity × total number of patients with advanced PD (41.9% x 702 = 294).
¥ the number of false negatives was calculated as follows: total number of patients with advanced PD – true positives (702–294 = 408).
* the number of true negatives was calculated as follows: specificity x total number of patients without advanced PD (96.2% x 4012 = 3860).
§ the number of false positives was calculated as follows: total number of patients without advanced PD – true negatives (4012–3860 = 152).

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