Table 2 Comparison between each SVD category
From: Sex-specific implications of inflammation in covert cerebral small vessel disease
Variables | Normal | Mild SVD | More-severe SVD | P value | Arteriosclerosis/lipohyalinosis | CAA | P value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Simple SVD score 0 n = 324 | Simple SVD score 1 n = 276 | Simple SVD score 2 or 3 n = 108 | SVD type 1 n = 246 | SVD type 2 n = 47 | SVD type 3 n = 56 | SVD type 4 n = 35 | |||||||||||
Age, years | 57.80 ± 5.87 | 64.71 ± 8.36 | 68.94 ± 8.59 | < 0.001 | 65.63 ± 8.12 | 67.86 ± 9.01 | 66.41 ± 9.98 | 64.35 ± 9.01 | < 0.001 | ||||||||
Gender | 0.060 | 0.206 | |||||||||||||||
Male | 129 (39.8%) | 135 (48.9%) | 52 (48.1%) | Â | 119 (48.4%) | 22 (46.8%) | 29 (51.8%) | 17 (48.6%) | Â | ||||||||
Female | 195 (60.2%) | 141 (51.1%) | 56 (51.9%) | Â | 127 (51.6%) | 25 (53.2%) | 27 (48.2%) | 18 (51.4%) | Â | ||||||||
HTN | 75 (23.1%) | 109 (39.5%) | 61 (56.5%) | < 0.001 | 106 (43.1%) | 23 (48.9%) | 30 (53.6%) | 11 (31.4%) | < 0.001 | ||||||||
DM | 23 (7.1%) | 52 (18.8%) | 25 (23.1%) | < 0.001 | 52 (21.1%) | 12 (25.5%) | 9 (16.1%) | 4 (11.4%) | < 0.001 | ||||||||
Dyslipidemia | 42 (13.0%) | 28 (10.1%) | 4 (3.7%) | 0.024 | 23 (9.3%) | 4 (8.5%) | 3 (5.4%) | 2 (5.7%) | 0.279 | ||||||||
Cigarette smoking | 44 (13.6%) | 44 (15.9%) | 18 (16.7%) | 0.625 | 39 (15.9%) | 10 (21.3%) | 7 (12.5%) | 6 (17.1%) | 0.643 | ||||||||
Homocysteine, umol/L | 11.24 (9.40-13.38) | 12.50 (10.80–15.40) | 13.00 (10.63–15.85) | < 0.001 | 12.70 (10.80–16.10) | 12.90 (10.10–15.90) | 12.30 (10.63–15.08) | 12.40 (10.20–14.80) | < 0.001 | ||||||||
hsCRP, mg/dL | 0.051 (0.020–0.142) | 0.077 (0.030–0.169) | 0.072 (0.026–0.190) | 0.005 | 0.077 (0.031–0.172) | 0.074 (0.039–0.205) | 0.094 (0.022–0.173) | 0.053 (0.022–0.138) | 0.015 | ||||||||