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Table 2 ORs and HRs with 95% CIs for the association between base excess and ICU/hospital/28-day/1-year mortality

From: Association between base excess and mortality in critically ill patients with ischemic stroke: a retrospective cohort study

Regression models

Base excess (mmol/L)

-3–3

< -3

> 3

ICU mortality

 

OR (95%CI)

P-value

OR (95%CI)

P-value

Event, n (%)

139 (12.90)

77 (24.40)

 

26 (14.90)

 

Univariable model

1 (ref)

2.183 (1.597–2.984)

< 0.001

1.183 (0.752–1.860)

0.468

Multivariable Model 1

1 (ref)

1.768 (1.263–2.475)

0.001

1.193 (0.757–1.880)

0.447

Multivariable Model 2

1 (ref)

1.780 (1.264–2.507)

0.001

1.229 (0.775–1.949)

0.381

Multivariable Model 3

1 (ref)

1.795 (1.266–2.546)

0.001

1.293 (0.809–2.066)

0.283

Multivariable Model 4

1 (ref)

1.829 (1.281–2.612)

0.001

1.190 (0.737–1.921)

0.477

Hospital mortality

 

OR (95%CI)

P-value

OR (95%CI)

P-value

Event, n (%)

124 (20.70)

97 (30.70)

 

34 (19.40)

 

Univariable model

1 (ref)

1.695 (1.280–2.244)

< 0.001

0.923 (0.617–1.379)

0.695

Multivariable Model 1

1 (ref)

1.448 (1.072–1.957)

0.016

0.928 (0.620–1.388)

0.715

Multivariable Model 2

1 (ref)

1.454 (1.069–1.978)

0.017

0.938 (0.622–1.415)

0.760

Multivariable Model 3

1 (ref)

1.460 (1.066–2.001)

0.019

0.955 (0.628–1.452)

0.829

Multivariable Model 4

1 (ref)

1.484 (1.077–2.045)

0.016

0.877 (0.572–1.344)

0.547

28-day mortality

 

HR (95%CI)

P-value

HR (95%CI)

P-value

Event, n (%)

264 (24.40)

117 (37.00)

 

39 (22.30)

 

Univariable model

1 (ref)

1.664 (1.339–2.069)

< 0.001

0.901 (0.644–1.261)

0.543

Multivariable Model 1

1 (ref)

1.499 (1.187–1.893)

0.001

0.908 (0.649–1.271)

0.573

Multivariable Model 2

1 (ref)

1.489 (1.180–1.879)

0.001

0.895 (0.639–1.253)

0.517

Multivariable Model 3

1 (ref)

1.482 (1.173–1.873)

0.001

0.928 (0.660–1.304)

0.668

Multivariable Model 4

1 (ref)

1.522 (1.200-1.929)

0.001

0.884 (0.628–1.244)

0.480

1-year mortality

 

HR (95%CI)

P-value

HR (95%CI)

P-value

Event, n (%)

389 (36.00)

165 (52.20)

 

70 (40.00)

 

Univariable model

1 (ref)

1.678 (1.399–2.014)

< 0.001

1.104 (0.856–1.424)

0.446

Multivariable Model 1

1 (ref)

1.468 (1.207–1.785)

< 0.001

1.119 (0.867–1.443)

0.387

Multivariable Model 2

1 (ref)

1.483 (1.221–1.802)

< 0.001

1.079 (0.836–1.392)

0.559

Multivariable Model 3

1 (ref)

1.405 (1.153–1.711)

0.001

1.052 (0.812–1.363)

0.701

Multivariable Model 4

1 (ref)

1.399 (1.148–1.705)

0.001

1.051 (0.811–1.361)

0.707

  1. Multivariable Model 1 was adjusted for the SOFA score
  2. Multivariable Model 2 was adjusted for model 1 plus age, sex, and ethnicity
  3. Multivariable Model 3 was adjusted for model 2 plus admission diagnoses including diabetes, hypertension, hyperlipemia, malignant neoplasm, chronic kidney disease, heart failure, chronic hepatic failure, chronic respiratory failure, sepsis, disseminated intravascular coagulation, pneumonia and diarrhea
  4. Multivariable Model 4 was adjusted for model 3 plus treatment measures, including vasoactive drugs, sedatives, anticoagulants, mannitol, mechanical ventilation
  5. ICU, intensive care unit; SOFA, Sequential Organ Failure Assessment; OR, odds ratio; HR, hazard ratio; CI, confidence interval
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BMC Neurology

ISSN: 1471-2377

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