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Table 2 Results of the active standing test

From: Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder

 

ALL

BT (+)

BT (-)

 

Effect size

(n = 43)

(n = 17)

(n = 26)

p-value

BT (+)—BT (-)

Systolic BP (mm Hg)

 Baseline

130.4 ± 16.8

130.9 ± 17.3

130.0 ± 16.9

0.874

0.049

 ΔsBP at 1 min after standing

-11.0 ± 12.6

-20.0 ± 11.5

-5.2 ± 9.7

 < 0.001

-1.391

 ΔsBP at 2 min after standing

-8.7 ± 11.9

-16.7 ± 12.0

-3.5 ± 8.5

 < 0.001

-1.288

 ΔsBP at 3 min after standing

-9.1 ± 11.1

-17.3 ± 11.3

-3.8 ± 7.0

 < 0.001

-1.480

Diastolic BP (mm Hg)

 Baseline

79.8 ± 9.0

81.0 ± 11.1

79.0 ± 7.4

0.486

0.215

 ΔdBP at 1 min after standing

-3.4 ± 7.9

-8.7 ± 7.2

0.1 ± 6.2

 < 0.001

-1.309

 ΔdBP at 2 min after standing

-2.0 ± 8.1

-7.7 ± 8.2

1.8 ± 5.5

 < 0.001

-1.405

 ΔdBP at 3 min after standing

-2.5 ± 7.1

-7.7 ± 6.7

0.8 ± 5.1

 < 0.001

-1.437

HR (bpm/min)

 Baseline

65.9 ± 9.4

67.0 ± 9.9

65.2 ± 9.3

0.562

0.179

 ΔHR at 1 min after standing

5.8 ± 6.0

4.0 ± 3.7

7.0 ± 6.8

0.100

-0.516

 ΔHR at 2 min after standing

5.7 ± 6.0

2.9 ± 3.1

7.5 ± 6.8

0.014

-0.788

 ΔHR at 3 min after standing

5.5 ± 6.2

2.3 ± 3.1

7.7 ± 6.9

0.004

-0.926

ΔHR/ΔsBP (bpm/mm Hg)

 ΔHR/ΔsBP at 1 min after standinga

0.66 ± 0.65

0.26 ± 0.21

1.01 ± 0.71

 < 0.001

-1.357

 ΔHR/ΔsBP at 2 min after standingb

1.03 ± 1.83

0.31 ± 0.39

1.85 ± 2.43

0.019

-0.890

 ΔHR/ΔsBP at 3 min after standingc

0.93 ± 1.54

0.17 ± 0.15

1.57 ± 1.88

0.004

-0.983

Orthostatic hypotension [n, %]

10 [23.3%]

8 [47.1%]

2 [7.7%]

0.003

N/A

Spine hypertension [n, %]

14 [32.6%]

6 [35.3%]

8 [30.8%]

0.757

N/A

Heart rate variability

 SDNN (ms)d

18.3 ± 9.9

16.6 ± 10.5

19.2 ± 9.7

0.472

-0.255

 RMSSD (ms)d

13.8 ± 9.1

14.4 ± 11.9

13.5 ± 7.4

0.765

0.106

 pNN50 (%)d

1.9 ± 5.2

2.9 ± 7.5

1.3 ± 3.4

0.407

0.294

 Poincaré plots, SD1 (ms)d

9.8 ± 6.4

10.2 ± 8.4

9.5 ± 5.2

0.765

0.106

 Poincaré plots, SD2 (ms)d

23.8 ± 12.8

21.0 ± 12.4

25.3 ± 13.0

0.355

-0.329

 Poincaré plots, SD1/SD2d

0.41 ± 0.14

0.45 ± 0.16

0.39 ± 0.12

0.273

0.391

  1. Abbreviations: BT blunted tachycardia, BP blood pressure, sBP systolic BP, dBP diastolic BP, HR heart rate, SDNN standard deviation of the NN intervals, RMSSD root mean square of successive differences, pNN50 percentage of difference between adjacent normal. RR intervals greater than 50 ms, SD1 Standard Deviation 1 of the Poincaré plot, SD2 Standard Deviation 2 of the Poincaré plot
  2. aBecause ΔHR/ΔSBP was not calculated in patients with increased sBP at 1 min after standing, the number of patients was set to n = 34 for All, n = 16 for BT(+), and n = 18 for BT(-)
  3. bBecause ΔHR/ΔSBP was not calculated in patients with increased sBP at 2 min after standing, the number of patients was set to n = 30 for All, n = 16 for BT(+), and n = 14 for BT(-)
  4. cBecause ΔHR/ΔSBP was not calculated in patients with increased sBP at 3 min after standing, the number of patients was set to n = 37 for All, n = 17 for BT(+), and n = 20 for BT(-)
  5. dBecause of the exclusion due to comorbidity or measurement errors, n = 34 in All; n = 12 in BT(+); n = 22 in BT(-)
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BMC Neurology

ISSN: 1471-2377

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