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Table 4 Odds ratios and interaction analyses for cryptogenic stroke

From: Role of interatrial block in modulating cryptogenic stroke risk in patients with patent foramen ovale: a retrospective study

 

Model 0

Model 1

Model 2

Variates

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

No-IAB/no-PFO

1(reference)

/

1(reference)

/

1(reference)

/

No-IAB/low-risk PFO

0.732 (0.334, 1.606)

0.437

0.837 (0.375, 1.870)

0.665

0.529 (0.224, 1.250)

0.147

No-IAB/high-risk PFO

3.169 (1.652, 6.079)

0.001

3.352 (1.727, 6.504)

 < 0.001

3.411 (1.709, 6.806)

0.001

IAB/no-PFO

1.590 (0.939, 2.692)

0.085

1.416 (0.827, 2.424)

0.205

1.424 (0.810, 2.505)

0.219

IAB/low-risk PFO

4.225 (1.635, 10.919)

0.003

3.804 (1.459, 9.918)

0.006

3.780 (1.416, 10.087)

0.008

IAB/high-risk PFO

5.650 (2.370, 13.469)

 < 0.001

5.127 (2.133, 12.325)

 < 0.001

5.450 (2.199, 13.504)

 < 0.001

MI-1

3.653 (1.115, 12.506)

0.037

3.546 (1.096, 11.412)

0.046

4.291 (1.137, 16.191)

0.032

MI-2

1.204 (0.378, 3.841)

0.753

1.180 (0.365, 3.818)

0.782

1.101 (0.330, 3.672)

0.876

AP-1

0.684 (0.333, 1.050)

 < 0.001

0.672 (0.299, 1.044)

 < 0.001

0.709 (0.355, 1.063)

 < 0.001

RERI-1

2.973 (-1.044, 6.989)

0.073

2.702 (-1.052, 6.455)

0.079

2.672 (-0.930, 6.273)

0.073

SI-1

8.984 (0.424, 190.576)

0.079

9.418 (0.278, 319.151)

0.106

28.968 (4*10–4, 2*106)

0.277

AP-2

0.396 (-0.217, 1.003)

0.101

0.334 (-0.351, 1.020)

0.169

0.322(-0.388, 1.031)

0.187

RERI-2

2.683 (-3.538, 8.905)

0.199

2.073 (-3.775, 7.920)

0.244

1.968 (-3.923, 7.860)

0.256

SI-2

1.867 (0.547, 3.369)

0.159

1.663 (0.466, 5.935)

0.217

1.624 (0.446, 5.912)

0.231

  1. AP attributable portion, CI confidence interval, HDL high density lipoprotein, IAB interatrial block, MI multiplicative interaction between IAB and PFO, OR odds ratio, PFO patent foramen ovale, RERI relative excess risk due to interaction, SI synergy index of interaction, -1 interaction between IAB and low-risk PFO compared with no-PFO, -2 interaction between IAB and high-risk PFO compared with no-PFO
  2. Model 0: including PFO, IAB and interaction terms
  3. Model 1: Model 0 + age and sex
  4. Model 2: Model 0 + age, sex, alcohol, smoking, hypertension, diabetes, fibrinogen, D-dimer, estimated glomerular filtration rate; homocysteine, high/low density lipoprotein and left atrial dimension
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BMC Neurology

ISSN: 1471-2377

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