Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel

Table 3 Association among NAD⁺ levels and QLQ-CIPN20 subscales scores over Time

Variable	Whole Sample		Paclitaxel		Vincristine
Variable	Estimate	p	Estimate	p	Estimate	p
QLQ-CIPN20 Sensory Subscale	-0.02	0.28	-0.02	0.41	-0.05	0.61
Anxiety	-0.02	0.60	0.009	0.84	-0.08	0.24
Depression	-0.05	0.27	-0.08	0.12	-0.01	0.96
Time	0.09	0.79	-0.02	0.96	0.63	0.54
	Estimate	p	Estimate	p	Estimate	p
QLQ-CIPN20 Motor Subscale	-0.02	0.17	-0.01	0.57	-0.07	0.08
Anxiety	-0.02	0.54	0.01	0.82	-0.08	0.23
Depression	-0.04	0.30	-0.08	0.13	-0.001	0.99
Time	0.09	0.79	-0.02	0.95	0.57	0.52
	Estimate	p	Estimate	p	Estimate	p
QLQ-CIPN20 Numbness and Tingling Items	-0.02	0.22	-0.02	0.15	-0.01	0.81
Anxiety	-0.02	0.58	0.003	0.94	-0.08	0.29
Depression	-0.05	0.26	-0.07	0.16	-0.003	0.98
Time	0.12	0.71	0.01	0.97	0.60	0.58

Notes:
A GEE model accounting for repeated measures across the three time points (time), and preliminarily assuming an independence correlation structure across time points was used to assess the association among the 4th root of the NAD⁺ area and QLQ-CIPN20 scores adjusting for anxiety and depression severity. The values approximate the change in the 4th root of the NAD⁺ area associated with a one-point increase in the respective variables

ISSN: 1471-2377