Association of critical hypoperfusion biomarkers on CT with futile recanalization and poor outcome after mechanical thrombectomy in acute ischemic stroke

Table 3 Association of factors with favorable outcome (mRS 0–2) in the univariable analysis

Factor	Odds ratio	95% CI	P value
Age	0.979	0.941–1.019	0.304
Female sex	0.436	0.174–1.019	*0.076*
Hypertension	1.728	0.648–4.610	0.274
Diabetes	0.777	0.274–2.204	0.636
Ischemic heart disease	0.727	0.188–2.807	0.664
Atrial fibrillation	0.545	0.210–1.411	0.211
TIA	1.818	0.287–11.536	0.526
Alcohol	0.615	0.222–1.707	0.351
History of smoking	1.083	0.427–2.749	0.866
INR	0.674	0.064–6.804	0.726
IV thrombolysis	1.192	0.445–3.193	0.726
Location of occlusion
MCA			0.628
ICA	1.406	0.307–6.431	0.660
T-type	2.333	0.463–14.613	0.365
TOAST
Large-artery atherosclerosis			0.182
Cardioembolism	1.160	0.069–19.519	0.918
Other determined etiology	0.438	0.500-8.036	0.578
Admission NIHSS	0.905	0.815–1.004	*0.059*
OTI	0.964	0.872–1.067	0.481
OTR	0.981	0.939–1.025	0.394
Volume of rCBF < 30%	0.975	0.948–1.003	*0.083*
Mismatch Volume	0.998	0.992–1.003	0.419
Mismatch Ratio	0.989	0.967–1.011	0.320
Volume of Tmax > 4s	0.998	0.994–1.003	0.449
Volume of Tmax > 6s	0.997	0.992–1.002	0.243
Volume of Tmax > 8s	0.993	0.984–1.001	*0.086*
Volume of Tmax > 10s	0.990	0.980–1.001	*0.073*
Volume of Tmax > 12s	0.986	0.971-1	*0.055*
HIR	0.008	0.001–0.254	*0.006*

Abbreviations 95% CI = 95% Confidence Interval; ASPECTS = Alberta Stroke Program Early Computed Tomography Score; NIHSS = National Institutes of Health Stroke Scale; OTI = Onset-to-Imaging Time; INR = International Normalized Ratio; TIA = Transient Ischemic Attack. Six variables in italic were significant at the p < 0.1 level and entered to the multivariable-integrated model for predicting poor/good outcomes; TOAST = Trial of Org 10,172 in Acute Stroke Treatment. T-type = TOAST type

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