Fig. 2
From: Highly prevalent geriatric medications and their effect on β-amyloid fibril formation
Cytotoxicity of 18 highly recommended drugs in the ND, MCI, and AD cohorts was determined by using the LDH assay. N2A (A) and SH-SY5Y (B) cells were incubated with 25 µM for 24 h, and LDH activity in the culture medium was measured. The drug components Lipitor, Colace, Plavix, and Norvasc significantly increased LDH activity in N2A cells. Only two drugs, vitamin D and Norvasc showed toxicity to SHSHy-5Y cells. Levothyroxine and Colace significantly reduce LDH activity compared to DMSO in SHSY-5Y cells. * indicates p ≤ 0.05, *** indicates p ≤ 0.001 (Student’s t test, N = 3)