Fig. 3
From: Highly prevalent geriatric medications and their effect on β-amyloid fibril formation
Alteration of Aβ aggregation by drugs with a high prevalence. (A) The amount of fibrils in the 25 µM drugs and 10 µM Aβ42 reaction mixtures was measured by ThT assay after 6 h of incubation. (B) Similarly, a ThT assay was performed after 48 h of incubation. Multiple drug components, including vitamin D3, levothyroxine, Prilosec, Flomax, and Norvasc significantly reduced the amount of fibrils when Aβ42 was incubated for longer durations. * indicates p ≤ 0.05, ** indicates p ≤ 0.01 *** indicates p ≤ 0.001 (Student’s t-test, N = 3)