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Table 1 Cochran’s Q test, MR-Egger Intercept and MR-PRESSO of MR analysis for serum 25-Hydroxyvitamin D levels and post-stroke outcome at 3 months

From: Genetic association between serum 25-hydroxyvitamin D levels and functional outcome after ischemic stroke

 

Cochran’s Q Test

MR—Egger

MR-PRESSO

Functional Outcome of Stroke (without adjusting for stroke severity)

Exposure

Outcome

IVW_Q_P value

Egger_intercept

P value

Global P value

P value

Serum 25-Hydroxyvitamin D levels

mRS (0–1) VS mRS (2–6) at 3 months

0.064

-0.0014

0.884

0.053

0.691

Serum 25-Hydroxyvitamin D levels

mRS (0–2) VS mRS (3–6) at 3 months

0.839

0.0061

0.468

0.851

0.051

Serum 25-Hydroxyvitamin D levels

mRS at 3 months

0.292

-0.0106

0.130

0.260

0.258

Functional Outcome of Stroke (adjusting for stroke severity)

Exposure

Outcome

IVW_Q_P value

Egger_intercept

P value

Global P value

P value

Serum 25-Hydroxyvitamin D levels

mRS (0–1) VS mRS (2–6) at 3 months

0.004

0.0093

0.255

0.004

0.782

Serum 25-Hydroxyvitamin D levels

mRS (0–2) VS mRS (3–6) at 3 months

0.639

0.0036

0.572

0.656

0.153

Serum 25-Hydroxyvitamin D levels

mRS at 3 months

0.119

-0.0106

0.13

0.336

0.450

  1. MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier