Table 1 Clinical parameters in different phenotypes of PON
Characteristic | ^Isolated ON = 5 (45%) n(%) | ^^MS ON = 1 (9%) n(%) | **NMSOD = 1 (9%) n(%) | ***ADEM = 1 (9%) n(%) | MOG = 3(27.2%) n(%) | Total = 11 n(%) |
|---|---|---|---|---|---|---|
Age (years) | Â | Â | ||||
> 10 | 4 (80) | o | 0 | 0 | 0 | 4 (36.3) |
< 10 | 1 (20) | 1(100) | 1 (100) | 1(100) | 3 (100) | 7 (63.6) |
Gender | Â | Â | ||||
Male | 4(80) | 0 | 1(100) | 0 | 2 (66.7) | 7 (63.6) |
Female | 1 (20) | 1(100) | 0 | 1(100) | 1 (33.3) | 4 (36.3) |
Eye involvement | Â | Â | ||||
Unilateral | 1 (20) | 1(100) | 0 | 0 | 1 (33.3) | 3 (27.2) |
Bilateral | 4 (80) | 0 | 1(100) | 1(100) | 2 (66.7) | 8 (72.7) |
Presenting symptoms | Â | Â | ||||
Headache | 2(40) | 0 | 1(100) | 0 | 2 (66.7) | 5 (45.4) |
Blurred /decreased vision | 2(40) | 1(100) | 1(100) | 0 | 2 (66.7) | 6 (54.5) |
Eye pain | 1 (20) | 1(100) | 0 | 1(100) | 1 (33.3) | 4 (36.3) |
Ocular signs | Â | Â | ||||
Visual field loss | 4(80) | 1(100) | 1 (100) | 1(100) | 0 | 7 (63.6) |
Color Vision loss | 0 | 1(100) | 1(100) | 0 | 0 | 2 (18.1) |
Visual acuity at presentation | Â | Â | ||||
> 20\20 | 1 (20) | 0 | 0 | 0 | 0 | 1 (9) |
< 20\20–20/40 | 1 (20) | 0 | 1(100) | 0 | 1 (33.3) | 3 (27.2) |
< 20\40 − 20\200 | 1 (20) | 1(100) | 0 | 0 | 2 (66.7) | 4 (36.3) |
< 20\200 − 20/400 | 2 (40) | 0 | 0 | 1(100) | 0 | 3 (27.7) |
Fundoscopy | Â | Â | ||||
Disc swelling | 3 (60) | 1(100) | 1 (100) | 1(100) | 1 (33.3) | 7 (63.6) |
Disc pallor | 2 (40) | 0 | 0 | 1(100) | 2 (66.7) | 5 (45.4) |
Normal Disc | 1 (20) | 0 | 0 | 0 | 0 | 1 (9) |
Treatment | Â | Â | ||||
*ONTT protocol | 5 (100) | 1 | 0 | 0 | 0 | 6 ( 54.5) |
ONTT protocol + IVIG | 0 | 0 | 0 | 1 | 0 | 1 (9) |
ONTT protocol + Rituxamab | 0 | 0 | 1 (100) | 0 | 0 | 1 (9) |
ONTT protocol + IVIG^^+ Rituxamab | 0 | 0 | 0 | 0 | 3 (100) | 3 (27.2) |
Visual acuity at 6 months | ||||||
>/=20\20 | 1(20) | 0 | 1 (100) | 1(100) | 1 (33.3) | 4 (36.6) |
< 20\20–20/40 | 2 (40) | 1(100) | 0 | 0 | 2 (66.7) | 5 (44.5) |
< 20\40 − 20\200 | 2(40) | 0 | 0 | 0 | 0 | 2 (18.1) |
< 20\200 − 20/400 | 0 | 0 | 0 | 0 | 0 | 0 |
Recurrence | ||||||
Yes | 1 (20) | 1 (100) | 1 (100) | 1 (100) | 1 (33.3) | 5 (45.4 |