Table 1 Inclusion criteria for NCDC cohorts

1

Inclusion of individuals without dementia at baseline.

2

Studies should not have a single focus on rare genetic forms of dementia

3

Baseline or follow-up data available after age 60

4

Detailed and repeated assessments of cognitive function or specialist verified diagnosis of dementia and its subtypes

5

In addition, collection at baseline of at least 4 of the following modalities: (1) genetics, (2) vascular risk factors, (3) psychosocial risk factors, (4) metabolomics or inflammation markers, (5) amyloid pathology (plasma, CSF, PET), (6) vascular pathology (MRI), (7) brain atrophy and connectivity (MRI), (8) comorbidities (e.g. stroke, depression, coronary heart disease)

6

Ongoing data collection. Cohorts with a closed follow-up that meet all other criteria could participate as an affiliated cohort

7

Existing infrastructure for systematic follow-up of participants, i.e. on health status, including dementia and cognitive impairment

8

Investigators related to that cohort have a longstanding track-record in the field of dementia and Alzheimer’s disease