The joint effects of inflammation and renal function status on in-hospital outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis

Table 3 The joint effects of CRP and eGFR on clinical outcomes after ischemic stroke treated with IVT

	Groups by levels of baseline CRP and eGFR
	CRP↓/eGFR↑	CRP↓/ eGFR↓	CRP↑/ eGFR↑	CRP↑/ eGFR↓	P trend
Post-stroke Pneumonia
No. (%) of cases	20 (12.8)	22 (14.9)	8 (21.1)	36 (53.7)
Model 1	1.00	1.19 (0.62–2.28)	1.81 (0.73–4.51)	7.90 (4.04–15.46)	< 0.001
Model 2	1.00	0.57 (0.21–1.58)	1.18 (0.38–3.66)	4.76 (1.73–13.10)	< 0.001
Functional outcome
No. (%) of cases	31 (17.7)	54 (30.3)	8 (42.1)	27 (73.0)
Model 1	1.00	2.02 (1.22–3.34)	3.38 (1.26–9.09)	12.54 (5.51–28.56)	< 0.001
Model 2	1.00	1.73 (0.80–3.73)	1.75 (0.56–5.43)	5.51 (1.95–15.55)	0.002

Data are Odds ratios (95% confidence intervals)
Model 1: unadjusted logistic regression model
Model 2: adjusted for age, sex, current smoking, admission NIHSS score, great vessels, medical history (hypertension, hyperglycemia, hyperlipidemia and coronary heart disease), history of stroke, ischemic stroke syndrome, use of anticoagulant and antiplatelet medication, duration of hospitalization
Abbreviations CRP C-reactive protein, eGFR estimated glomerular filtration rate

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