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Table 4 Performance of models with inflammatory biomarkers and eGFR for clinical outcomes after ischemic stroke treated with IVT

From: The joint effects of inflammation and renal function status on in-hospital outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis

 

NRI (category free)

IDI

 

Estimate (95% CI), %

P value

Estimate (95% CI), %

P value

Post-stroke Pneumonia

 Basic model

Reference

 

Reference

 

 Basic model + WBC + eGFR

69.0 (47.3–90.7)

 < 0.001

5.4 (2.6–8.3)

 < 0.001

 Basic model + CRP + eGFR

71.3 (49.1–93.4)

 < 0.001

8.4 (4.2–12.6)

 < 0.001

Functional outcome

 Basic model

Reference

 

Reference

 

 Basic model + WBC + eGFR

59.4 (39.2–79.7)

 < 0.001

5.3 (2.9–7.8)

 < 0.001

 Basic model + CRP + eGFR

27.5 (71.3–47.9)

0.01

2.8 (0.8–4.9)

0.008

  1. Basic model included age, sex, current smoking, admission NIHSS score, great vessels, medical history (hypertension, hyperglycemia, hyperlipidemia and coronary heart disease), history of stroke, ischemic stroke syndrome, use of anticoagulant and antiplatelet medication, duration of hospitalization
  2. Abbreviations: WBC White blood cell, CRP C-reactive protein, eGFR estimated glomerular filtration rate, CI Confidence interval, IDI Integrated discrimination improvement, NRI Net reclassification index
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BMC Neurology

ISSN: 1471-2377

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