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Table 3 Univariate logistic and multivariable logistic regression models evaluating the association between blood glucose and WMLs

From: Asymmetric U-shaped relationship between blood glucose and white matter lesions: results of a cross-sectional study

Variable

Univariate logistic analysis

P-value

Multivariable logistic analysis

P-value

 

OR (95%CI)

 

OR (95%CI)

 

BS <95(mg/dl)

1.308 (1.013–1.688)

0.039

1.493 (1.106–2.014)

0.009

BS 95–100(mg/dl)

1(Ref)

 

1(Ref)

 

BS 101–107(mg/dl)

1.092 (0.844–1.414)

0.504

0.999 (0.736–1.357)

0.995

BS >107(mg/dl)

2.185 (1.695–2.816)

< 0.001

1.499 (1.068–2.102)

0.0192

Age(years)

7.45 (6.04–9.189)

< 0.001

4.915 (3.87–6.242)

< 0.001

Gender, n(%)

1.542 (1.286–1.85)

< 0.001

1.446 (1.093–1.914)

0.010

PS

1.36 (1.276–1.45)

< 0.001

1.003 (0.809–1.244)

0.977

LDL(mg/dl)

1.002 (0.999–1.005)

0.109

0.999 (0.989–1.008)

0.771

HDL(mg/dl)

1.013 (1.007–1.019)

< 0.001

1.024 (1.006–1.042)

0.009

TG

0.999 (0.998-1)

0.146

1 (0.998–1.001)

0.778

Plaque, M(IQR)

1.782 (1.592–1.995)

< 0.001

1.326 (0.888–1.982)

0.168

LH

0.894 (0.793–1.006)

0.064

1.334 (0.794–2.244)

0.276

HbA1c(%)

1.917 (1.578–2.328)

< 0.001

1.06 (0.838–1.342)

0.627

BMI(kg/m2)

1.004 (0.978–1.031)

0.774

0.977 (0.937–1.02)

0.289

MAP(mmHg)

1.024 (1.017–1.032)

< 0.001

1.018 (1.009–1.027)

< 0.001

smoking, n(%)

0.517 (0.407–0.657)

< 0.001

0.854 (0.631–1.156)

0.306

Amount of drink < 180ML/day

1(Ref)

 

1(Ref)

 

Amount of drink (180ML-360ML/day)

0.679 (0.548–0.842)

< 0.001

0.869 (0.634–1.19)

0.380

Amount of drink (360ML-540ML/day)

0.543 (0.388–0.758)

< 0.001

0.738 (0.475–1.149)

0.179

Amount of drink > 540ML/day

0.583 (0.339–1.004)

0.052

1.038 (0.537–2.009)

0.911

Cholesterol-lowering drugs, n(%)

2.726 (2.08–3.571)

< 0.001

1.359 (0.964–1.917)

0.080

Drink habit(Rarely drink), n(%)

1(Ref)

 

1(Ref)

 

Drink habit(Sometimes), n(%)

0.783 (0.63–0.973)

0.0274

1.274 (0.957–1.695)

0.097

Drink habit(Everyday), n(%)

0.775 (0.622–0.965)

0.022

1.113 (0.791–1.567)

0.538

Insulin, n(%)

2.955 (1.969–4.434)

< 0.001

1.141 (0.645–2.021)

0.650

Metabolic syndrome(No), n(%)

1(Ref)

 

1(Ref)

 

Metabolic syndrome(Reserve), n(%)

1.371 (1.012–1.858)

0.042

1.868 (1.254–2.784)

0.002

Metabolic syndrome(Yes), n(%)

1.822 (1.392–2.385)

< 0.001

1.296 (0.855–1.963)

0.222

Antihypertensive drugs, n(%)

3.52 (2.773–4.467)

< 0.001

1.798 (1.33–2.432)

< 0.001

  1. Abbreviations: BS, blood glucose; PS, carotid plaque score; LDH, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; TG, triglyceride; HbA1c, hemoglobin A1c; LH, ratio of LDL to HDL; BMI, body mass index; MAP, mean arterial pressure; Plaque N, plaque number; OR, odds ratio; CI, confidence interval; Ref, reference