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Table 1 The MR analysis results of BAFF-R related traits on NPH

From: Causal relationship between Baff-R expression and normal pressure hydrocephalus: insights from Mendelian randomization analysis

Exposure

Methods

nSNPs

OR (95%CI)

P

BAFF-R on unswitched memory B cell

IVW

12

0.90 (0.82, 0.98)

0.021

MR Egger

12

0.89 (0.79, 1.01)

0.107

Weighted median

12

0.92 (0.82, 1.02)

0.111

Weighted mode

12

0.91 (0.82, 1.01)

0.095

Simple mode

12

0.83 (0.68, 0.99)

0.069

BAFF-R on IgD + CD38- B cell

IVW

13

0.90 (0.82, 0.98)

0.021

MR Egger

13

0.92 (0.81, 1.03)

0.189

Weighted median

13

0.91 (0.82, 1.02)

0.092

Weighted mode

13

0.91 (0.81, 1.01)

0.104

Simple mode

13

0.87 (0.70, 1.07)

0.214

BAFF-R on CD24 + CD27 + B cell

IVW

15

0.90 (0.82, 0.99)

0.024

MR Egger

15

0.89 (0.78, 1.01)

0.087

Weighted median

15

0.92 (0.82, 1.02)

0.116

Weighted mode

15

0.90 (0.81, 1.00)

0.079

Simple mode

15

0.84 (0.69, 1.02)

0.099

BAFF-R on IgD- CD38- B cell

IVW

11

0.90 (0.82, 0.99)

0.028

MR Egger

11

0.88 (0.78, 1.01)

0.093

Weighted median

11

0.92 (0.82, 1.03)

0.137

Weighted mode

11

0.91 (0.81, 1.02)

0.125

Simple mode

11

0.88 (0.74, 1.04)

0.160

BAFF-R on IgD + CD38dim B cell

IVW

17

0.91 (0.83, 0.99)

0.030

MR Egger

17

0.89 (0.79, 1.01)

0.085

Weighted median

17

0.91 (0.82, 1.02)

0.098

Weighted mode

17

0.91 (0.81, 1.01)

0.097

Simple mode

17

0.87 (0.71, 1.06)

0.192

BAFF-R on IgD + CD24 + B cell

IVW

12

0.90 (0.82, 0.99)

0.031

MR Egger

12

0.89 (0.78, 1.01)

0.095

Weighted median

12

0.92 (0.82, 1.03)

0.128

Weighted mode

12

0.90 (0.81, 1.00)

0.074

Simple mode

12

0.84 (0.70, 1.01)

0.095

BAFF-R on IgD + CD38- naive B cell

IVW

17

0.91 (0.84, 1.00)

0.039

MR Egger

17

0.97 (0.84, 1.11)

0.635

Weighted median

17

0.92 (0.82, 1.03)

0.139

Weighted mode

17

0.92 (0.82, 1.03)

0.160

Simple mode

17

0.77 (0.59, 1.00)

0.070

BAFF-R on memory B cell

IVW

13

0.91 (0.83, 1.00)

0.043

MR Egger

13

0.87 (0.77, 0.98)

0.045

Weighted median

13

0.92 (0.82, 1.02)

0.113

Weighted mode

13

0.90 (0.80, 1.00)

0.084

Simple mode

13

0.85 (0.71, 1.03)

0.123

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BMC Neurology

ISSN: 1471-2377

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