Early venous filling is associated with unfavorable outcomes in acute ischemic stroke with large vessel occlusion after mechanical thrombectomy: a real-world analysis

Table 3 Association between poor clinical outcomes and EVF after mechanical thrombectomy in ASPECT score stratified analyses

	Total	EVF +	EVF-	OR(95%CI)	P
	n = 307	n = 75	n = 232	OR(95%CI)	P
Unfavorable outcome
Total	164(53.42%)	57(76.00%)	107(46.12%)	2.69(1.37–5.26)	0.004
ASPECT score > 8	70(46.36%)	21(72.41%)	49(40.16%)	2.73(0.96–7.70)	0.058
ASPECT score ≤ 8	94(60.26%)	36(78.26%)	58(52.73%)	2.64(1.03–6.73)	0.042
MBE
Total	59(19.21%)	28(37.33%)	31(13.36%)	3.06(1.56–6.01)	0.001
ASPECT score > 8	17(11.26%)	5(17.24%)	12(9.83%)	1.28(0.36–4.54)	0.699
ASPECT score ≤ 8	42(26.92%)	23(50.00%)	19(17.27%)	4.59(1.94–10.83)	< 0.001
HT
Total	107(34.85%)	43(57.33%)	64(27.59%)	2.98(1.64–5.42)	< 0.001
ASPECT score > 8	41(27.15%)	14(48.28%)	27(22.13%)	2.38(0.93–6.09)	0.070
ASPECT score ≤ 8	66(42.31%)	29(63.04%)	37(33.64%)	3.56(1.59–7.95)	0.002
SICH
Total	31(10.10%)	16(21.33%)	15(6.47%)	2.86(1.23–6.66)	0.041
ASPECT score > 8	6(3.97%)	2(6.90%)	4(3.28%)	1.67(0.26–10.72)	0.591
ASPECT score ≤ 8	25(16.02%)	14(30.43%)	11(10.00%)	4.10(1.55–10.86)	0.004

For unfavorable outcome: Adjusted for age, gender, baseline glucose, atrial fibrillation, coronary artery disease, baseline NIHSS score, baseline ASPECT score, mTICI score > 2b, number of device passes
For malignant brain edema: Adjusted for age, gender, baseline NIHSS score, baseline ASPECT score, baseline glucose, baseline neutrophil, coronary artery disease, OPT, number of device passes
For hemorrhagic transformation and symptomatic intracranial hemorrhage: Adjusted for age, gender, baseline glucose, occlusion site, baseline NIHSS score, baseline ASPECT score, number of device passes, endovascular stents
ASPECT Alberta Stroke Program Early CT, EVF Early venous filling, HT Hemorrhagic transformation, MBE Malignant brain edema, mTICI modified thrombolysis in cerebral infarction, NIHSS National Institutes of Health Stroke Scale, OPT time from stroke onset to puncture, SICH Symptomatic intracranial hemorrhage

ISSN: 1471-2377