Fig. 2

MR analysis of the validation cohort. The results of the IVW model showed that there is a significant causal relationship between exposure factors and outcome indicators (A). The results of the Cochran’s Q test showed that there was no heterogeneity (B). The results of the leave-one-out analysis showed that the overall relationship estimate was not significantly affected by any single SNP (C). The analysis of individual SNPs showed that some had a certain protective trend on outcome indicators (D)