Metagenomic next-generation sequencing for the diagnosis of Corynebacterium striatum meningitis: case report and literature review

Table 1 Summary of neurological cases of Corynebacterium striatum infection reported in the literature

Study	Our patient	Weiss [29]	Hoy [30]	Hoy [30]	Hoy [30]	Sűnbűl [31]	Sűnbűl [31]	Kammoun [32]	Zhang [33]
Gender/Age	M/75Y	M/23Y	M/20 M	F/13 M	F/6Y	M/17Y	F/58Y	M/28Y	F/54Y
Symptom	Headache, nausea, vomiting, fever	Headache, chills	Fever, irritable	Fever	Lethargic, fever	Fever	Headache, nausea, vomiting, fever	Fever, coma	Headache, blurred vision, vomiting, paraphasia
Susceptible factors	Malnutrition, hypoproteinae-mia	Cerebro-meningeal fistulas	Intracranial-external drainage catheter	Intracranial-external drainage catheter	Intracranial-external drainage catheter	Intracranial-external drainage catheter	Intracranial-external drainage catheter	Acquired pneumonia, urinary tract infection, fungemia	Skin injury, brain abscess, pulmonary abscess
CSF results	WBC:400; Cl⁻:118.4; Prot.: 0.88; Glu:2.83	WBC:1130; Glu:1.5; Prot.: 4.35;	NA	NA	NA	WBC:220; Glu:5.38; Prot.:2.29; Cl⁻:88.8;	WBC:270; RBC:12,000; Glu:3.11; Prot.:1.50; Cl⁻:111	WBC:240; Glu:0.28; Prot.:0.76	WBC:12,100; Prot.: 1.58; Glu:0.39
Principal treatment	Ceftriaxone, penicillin, vancomycin	Ceftriaxone vancomycin	Vancomycin	Chloramphenicol	Chloramphenicol vancomycin	Ampicillin cefotaxime, vancomycin	Ceftriaxone vancomycin	Imipenem, Colimycin vancomycin	Vancomycin, Meropenem
Outcome	Alive	Alive	Alive	Alive	Alive	Died	Alive	Died	Died

Abbreviations: CSF, cerebrospinal fluid; Prot., protein (g/L); WBC, white blood cell (cells/mm3); Cl-, chloride(mmol/L); Glu, glucose(mmol/L) NA, not available;

ISSN: 1471-2377