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Table 4 Correlation of [18F] AV45 with cognitive and biomarker measures across diagnostic groups

From: Growth associated protein 43 (GAP-43) predicts brain amyloidosis in Alzheimer’s dementia continuum: an [18 F] AV-45 study

 

CN

(n = 77)

MCI

(n = 111)

AD

(n = 38)

r

P value

r

P value

r

P value

Aβ42

-0.735

< 0.001a

-0.743

< 0.001a

-0.376

0.020a

T-tau

0.351

0.002a

0.450

< 0.001a

0.282

0.087a

P-tau

0.425

< 0.001a

0.504

< 0.001a

0.569

< 0.001a

ADAS-Cog 13

0.096

0.405a

0.100

0.295a

0.169

0.309a

MMSE

-0.006

0.956a

-0.287

0.002a

-0.106

0.528a

CDR-SB

0.045

0.701a

0.154

0.107a

0.146

0.383a

  1. Abbreviations: CN: cognitively normal; MCI: mild cognitive impairment; AD: Alzheimer’s disease; MMSE: Mini-Mental State Examination; CDR-SB: Clinical Dementia Rating Scale-Sum of Boxes; ADAS-Cog 13: Alzheimer’s Disease Assessment Scale-Cognitive 13; T-tau: total tau; P-tau: phosphorylated tau; Aβ: amyloid-β; CSF: cerebrospinal fluid; GAP-43: Growth Associated Protien-43; a Spearman correlation
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BMC Neurology

ISSN: 1471-2377

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