Fig. 4

Correlation of intrathecal IL-6, NfL and GFAP with clinical scales. (A) IL-6 levels correlated with the EDSS, with a correlation coefficient (r) of 0.2663 and a p-value of 0.0320. (B) IL-6 levels also correlate with the MSSS, with r = 0.3261 and p = 0.0080. (C) NfL levels correlated with EDSS, albeit with a weaker correlation coefficient (r = 0.2093) and a non-significant p-value (p = 0.0943) (D) NfL levels correlated with MSSS, with r = 0.3030 and p = 0.0142. (E) GFAP levels in CSF correlate with EDSS, with r = 0.2935 and p = 0.0177. (F) GFAP levels correlated with MSSS, with r = 0.3947 and a highly significant p-value of 0.0011. All correlations were calculated using Spearman’s rank coefficient