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Table 1 Detection limits for the measurement of plasma proteins

From: Intrathecal interleukin-6 levels are associated with progressive disease and clinical severity in multiple sclerosis

Plasma proteins

Lower Limit of Quantification (LLOQ)

Upper Limit of Quantification (ULOQ)

SiMOA Planar Array®

Interleukin 1-beta (IL-1β)

0.02 pg/ml

100.00 pg/ml

Interleukin-4 (IL-4)

0.20 pg/ml

200.00 pg/ml

Interleukin-5 (IL-5)

0.05 pg/ml

200.00 pg/ml

Interleukin-6 (IL-6)

0.07 pg/ml

300.00 pg/ml

Interleukin-8 (IL-8)

0.10 pg/ml

400.00 pg/ml

Interleukin-10 (IL-10)

0.02 pg/ml

25.00 pg/ml

Interleukin 12, p70 subunit (IL-12p70)

0.07 pg/ml

300.00 pg/ml

Interleukin-22 (IL-22)

0.02 pg/ml

25.00 pg/ml

Interferon-gamma (IFN-ɣ)

0.01 pg/ml

50.00 pg/ml

Tumour Necrosis Factor-Alpha (TNF-α)

0.10 pg/ml

400.00 pg/ml

Simple Plex Human NfL Cartridge with an Ella®Automated Immunoassay System

Interleukin-6 (IL-6)

0.28 pg/ml

2652 pg/ml

Neurofilament Light Chain (NfL)

2.70 pg/ml

10,290.00 pg/ml

Glial Fibrillary Acidic Protein (GFAP)

72.1 pg/ml

110,000 pg/ml