Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis

BMC Neurology

Table 1 The forward Mendelian randomization of allergic disease and AD

Exposure	SNPs	Method	OR	95% CI	P value	Q_P value	Intercept (P value)
		IVW	0.609	0.188–1.973	0.408	0.193
allergic rhinitis	30	WM	0.551	0.149–2.036	0.371
		MR-Egger	0.901	0.017–48.291	0.959	0.178	-0.00020 (0.606)
		IVW	0.999	0.995–1.003	0.759	< 0.001
atopic dermatitis	20	WM	1.003	0.999–1.007	0.133
(raw)		MR-Egger	1.002	0.994–1.011	0.599	< 0.001	-0.00057 (0.449)
		IVW	1.000	0.995–1.005	0.902	0.001
atopic dermatitis	15	WM	1.004	0.999–1.008	0.072
(adjusted)		MR-Egger	1.007	0.998–1.018	0.191	0.002	-0.00153 (0.114)
		IVW	0.824	0.736–0.922	< 0.001	0.564
age of onset of asthma	19	WM	0.795	0.681–0.929	0.004
		MR-Egger	0.839	0.528–1.331	0.466	0.495	-0.00088 (0.937)
		IVW	1.024	0.935–1.121	0.610	< 0.001
age of onset of childhood onset asthma (raw)	21	WM	0.992	0.903–1.089	0.861
		MR-Egger	1.308	0.849–2.0164	0.238	< 0.001	-0.019521 (0.270)
		IVW	1.023	0.955–1.095	0.510	0.831
age of onset of childhood onset asthma (adjusted)	15	WM	0.990	0.903–1.085	0.828
		MR-Egger	0.864	0.569–1.315	0.509	0.819	0.0132 (0.440)

SNPs, single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval; IVW, inverse-variance weighted; WM, weight median; AD, Alzheimer’s disease

ISSN: 1471-2377