Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis

BMC Neurology

Table 2 The reverse Mendelian randomization of allergic disease and AD

Outcome	SNPs	Method	OR	95% CI	P value	Q_P value	Intercept (P value)
		IVW	1.001	0.998–1.003	0.589	0.123
allergic rhinitis	35	WM	1.002	0.999–1.004	0.108
		MR-Egger	1.000	0.997–1.004	0.699	0.176	-0.00002 (0.927)
		IVW	0.974	0.930–1.151	0.410	0.674
atopic dermatitis	35	WM	0.958	0.872–1.053	0.374
		MR-Egger	1.035	0.916–1.036	0.530	0.630	-0.00892 (0.183)
		IVW	0.991	0.983–0.999	0.040	< 0.001
asthma (raw)	37	WM	0.996	0.992–0.999	0.020
		MR-Egger	0.999	0.985–1.013	0.870	< 0.001	-0.00115 (0.193)
		IVW	0.994	0.990–0.997	< 0.001	0.871
asthma (adjusted)	31	WM	0.994	0.989–0.998	0.003
		MR-Egger	0.993	0.987–0.999	0.028	0.843	-0.000096 (0.749)

SNPs, single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval; IVW, inverse-variance weighted; WM, weight median; AD, Alzheimer’s disease

ISSN: 1471-2377