Table 2 MR analyses by IVW approach and sensitivity analyses of IL- 6 on potential mediators and AD
Classification | nSNP | IVW | Heterogeneilty | Pleiotropy | MR-PRESSO | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Exposure | Outcome | SE | P value | OR (95%CI) | Q | P value | Egger intercept | SE | P value | Global Test P-value | |
IL- 6 | CD28+ CD45RA− CD8br AC | 22 | 0.071 | 0.005 | 1.159 (1.007–1.333) | 18.339 | 0.627 | 0.001 | 0.016 | 0.961 | 0.657 |
AD | 22 | 0.023 | 0.009 | 0.941 (0.899–0.985) | 20.105 | 0.515 | − 0.008 | 0.006 | 0.156 | 0.529 | |