Table 4 Multivariate separate-sample MR analysis of the effect of IL- 6 on AD
Method | Estimate (95% CI) | P-value | Mediation effect (%) | |
|---|---|---|---|---|
Univariate Model | ||||
IL- 6 | IVW | − 0.061 (− 0.106, − 0.015) | 0.009 | |
Multivariate Model | ||||
Adjusted for CD28+ CD45RA− CD8br AC | IVW | − 0.046 (− 0.090, − 0.002) | 0.040 | 24.7 |