Association between sphingomyelin levels and gut microbiota abundance in Alzheimer’s disease: a two-sample Mendelian randomization study

Table 2 Assessment of heterogeneity using different methods (P > 0.05)

Exposure	Outcome	Method	Cochran’s Q	P value
Sphingomyelin levels	family Alcaligenaceae	MR Egger	31.035	0.973
	family Alcaligenaceae	Inverse variance weighted	33.333	0.958
	species Ruminococcus callidus	MR Egger	46.432	0.496
	species Ruminococcus callidus	Inverse variance weighted	46.746	0.524
	genus Flavonifractor	MR Egger	47.854	0.479
	genus Flavonifractor	Inverse variance weighted	48.563	0.491
	genus Streptococcus	MR Egger	50.538	0.374
	genus Streptococcus	Inverse variance weighted	50.94	0.397
	species Haemophilus parainfluenzae	MR Egger	52.466	0.379
	species Haemophilus parainfluenzae	Inverse variance weighted	53.123	0.392
	species Bacteroides caccae	MR Egger	54.595	0.27
	species Bacteroides caccae	Inverse variance weighted	54.81	0.297

ISSN: 1471-2377