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Table 3 Description of Levothyroxine treatment

From: Effectiveness of low dose thyroxine in patients with subclinical hypothyroidism and migraine; systematic review and meta-analysis

Study ID

Description of Low Dose Thyroxin

Dosage of Thyroxin Administered

Duration of Treatment

Description of Control Group

Dev, 2023 [22]

Patients take levothyroxine on an empty stomach an hour before food, and avoided medications that interfere with absorption or took it four hours or more after ingestion.

25 mg of levothyroxine supplementation

3 months

Both groups continued or received treatment for migraine prophylaxis.

Filipchuk, 2022 [31]

N/A

N/A

At least 6 months

A post-hoc case-control supplementary; selecting age, gender, and BMI matching controls from the episodic migraine sample database to be compared with the “cases” patients.

Hepp, 2018 [32]

Adherent

when they took LT4 at least 80% of the days in the postperiod

NA

1 year

Non-adherent to LT4

Lage, 2020 [33]

NA

  

Untreated with levothyroxine