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Table 2 Results of mediation analyses for DMV score, FW, and WMH volume

From: Deep medullary vein abnormalities impact white matter hyperintensity volume through increases in interstitial free water

 

Path a

β (95% CI)

Path b

β (95% CI)

Path c-direct effect

β (95% CI)

Path ab-indirect effect

β (95% CI)

Model 1

0.610 (0.468, 0.752)*

0.460 (0.272, 0.648)*

0.146 (-0.042, 0.334)

0.281 (0.178, 0.388)*

Model 2

0.405 (0.259, 0.552)*

0.351 (0.143, 0.559)*

0.100 (-0.088, 0.288)

0.142 (0.058, 0.240)*

Model 3

0.401 (0.254,0.549)*

0.351 (0.141,0.562)*

0.094 (-0.095,0.284)

0.141 (0.054,0.249)*

  1. *p < 0.05
  2. Model 1: DMV score serving as predictor, FW as mediator, and WMH volume as outcome; Model 2: Model 1, adjusted for age and gender; Model 3: Model 1, adjusted for age, gender, hypertension, Diabetes and hyperlipidemia
  3. CI, confidence interval; DMV, deep medullary vein; FW, free water; WMH, white matter hyperintensity
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BMC Neurology

ISSN: 1471-2377

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