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Nonmotor symptoms (NMSs) are under-recognized in progressive supranuclear palsy (PSP), despite their considerable impact on quality of life. The full spectrum and impact of NMSs in PSP remain insufficiently un...
The original article was published in BMC Neurology 2025 25:109
Neutrophil extracellular traps (NETs) released by neutrophils can exacerbate inflammation, leading to rupture of intracranial aneurysms (IA). This study aims to explore potential NETs-related genes in IA. RNA ...
The original article was published in BMC Neurology 2025 25:133
Intracerebral hemorrhage (ICH) is associated with a poor prognosis. The association between the neutrophil-to-albumin ratio (NAR) with mortality in patients with ICH remains underexplored. This study investiga...
Chronic stroke survivors are often left with residual arm muscle weakness impeding arm function, daily life activities and quality of life. Exercise is one of the main post-stroke interventions to improve arm ...
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder, with spastic paraplegia type 56 (SPG56) being an exceptionally rare, autosomal recessive subtype caused by mutations in the CYP2U1 gene. This s...
Pineal cyst is an uncommon condition in pregnancy. It is often encountered as an incidental finding. Most pineal cysts are benign and asymptomatic. Bleeding inside these cysts is rarely encountered in pregnancy.
Secondary central nervous system (CNS) Aspergillus fumigatus infection leading to subarachnoid hemorrhage following the onset of hemophagocytic lymphohistiocytosis (HLH) represents an extremely rare case. We prov...
Paraneoplastic cerebellar degeneration (PCD) is a rare neurological syndrome caused by a remote effect or immune response involving the cerebellum due to tumor. Here, we report a rare case of PCD secondary to ...
IL-6 has garnered significant attention as a potential factor in AD pathogenesis. The association between peripheral immune cells and IL-6 is evident, yet how peripheral immune cells mediate IL-6's effects on ...
Woven EndoBridge (WEB) is an endovascular treatment for wide-neck bifurcation aneurysms (WNBAs). This study aimed to clarify the efficacy and safety of the WEB comparing to clipping for treating the middle cer...
COVID-19 is a disease that affects people globally. Beyond affecting the respiratory system, COVID-19 patients are at an elevated risk for both venous and arterial thrombosis. This heightened risk contributes ...
In the last twenty years, epidemiological research has suggested a potential decreased susceptibility to cancer among individuals diagnosed with Parkinson’s disease (PD), although conflicting findings exist re...
The Kleefstra syndrome spectrum (KSS) is a group of neurodevelopmental disorders characterized by intellectual disability, behavioral disorders, growth and neurodevelopmental delay, facial dysmorphism and neur...
Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) levels alongside normal free thyroxine (T4) and triiodothyronine (T3) levels. Emerging evidence suggests a link between...
The phase 3 PREEMPT clinical trials confirmed the efficacy and safety of 155 U – 195 U onabotulinumtoxinA for individuals with chronic migraine (CM) and is the licensed dose in Canada and Europe. This analysis...
Ischemic stroke (IS) occurs when a blood clot obstructs a blood vessel supplying blood to the brain, leading to brain tissue damage due to insufficient oxygen and nutrients. The roles of immune cells and metab...
Tumor-related trigeminal neuralgia (TRTN) accounts for approximately 6% of all facial pain syndromes. Conventional medical treatments have short-term pain relief effects in TRTN cases; however, they are correl...
Seeking medical attention promptly after an acute stroke is essential for effective treatment and improved patient outcomes. However, delayed medical intervention after acute stroke contributes to increased mo...
Lower limb exoskeleton rehabilitation robot is a new technology to improve the lower limb motor function of stroke patients. Recovery of motor function after stroke is closely related to neuroplasticity in the...
Anaphylaxis is a common, severe, and life-threatening allergic reaction that occurs rapidly after exposure to an allergen which can affect multiple systems in the body. In rare cases, it may lead to additional...
Several previous observational studies have shown that abnormal sphingomyelin metabolism may be implicated in the pathogenesis of Alzheimer’s disease. To determine the causal relationship between sphingolipid ...
This study aims to evaluate the survival and mortality rates of stroke patients after receiving enteral nutrition, and to explore factors influencing long-term survival. With an aging society, nutritional mana...
To determine the correlation between intracranial atherosclerotic stenosis and high-sensitivity C-reactive protein (hs-CRP) levels in elderly patients with cerebral infarction.
Stroke is a leading cause of disability and mortality worldwide and existing global literature suggests that public knowledge of stroke symptoms is generally poor. Algorithms that encompass stroke alarm signs ...
The glymphatic system is a glial-based perivascular network that facilitates the clearance of metabolic waste from the brain. Dysfunction of the glymphatic system, along with neurological symptoms such as cogn...
Based on the near-infrared functional brain imaging system, this research studied the hemoglobin concentration signal in resting state and task state. The purpose of this research was to analyze the activated ...
Dengue encephalitis is a rare complication of dengue and can manifest as ischemic stroke, making the diagnosis challenging. This case highlights the need of recognizing unusual presentation of dengue and the u...
The aim of this study was to investigate the effects of anticoagulation with DOACs and warfarin on the characteristics of chronic subdural hematomas (CSDHs), specifically, the size of the hematomas, the presen...
LSVT®LOUD is an intensive speech therapy targeting voice amplitude, incorporating proprioceptive feedback and auditory-vocal self-monitoring, delivered through 16 one-hour sessions over a month with a high-eff...
Asymptomatic internal carotid artery occlusion (aICAO) disrupts cerebral blood flow and can impair brain function. While previous research has primarily focused on abnormal functional connectivity between brai...
This study seeks to determine if patients with high-grade glioma (HGG) demonstrate glymphatic system (GS) impairments using Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS). Additionally, it aims ...
The Uhthoff phenomenon (UP) is a temporary worsening of neurological symptoms due to an increase in body temperature, commonly observed in demyelinating diseases, especially multiple sclerosis (MS).
Paroxysmal Sympathetic Hyperactivity (PSH) is an under-recognized condition in pediatric patients, particularly those with non-traumatic brain injuries, often leading to delayed diagnosis and suboptimal manage...
Parkinson’s disease (PD) has emerged as a major global public health challenge. However, there is currently a lack of systematic analysis regarding the burden of PD and its long-term trends among people over 5...
Post-stroke fatigue (PSF) is a common complication following stroke that affects approximately 50% of stroke survivors.
A 56-year-old man presented with right-sided drooping of the mouth corner and eyelid, along with weakness in the left lower limb. His MRI revealed a corona radiata lacunar infarction on the left and an acute i...
To establish a nomogram prediction model for the patients with prolonged disorders of consciousness (PDOC) caused by brain injury at six months based on behavioral scale scores, neuroelectro-physiological tech...
Vascular disease in aging populations spans a wide range of disorders including strokes, circulation disorders and hypertension. As individuals age, vascular disorders co-occur and hence exert combined effects...
Numerous evidence from observational studies indicated an association between allergic diseases and Alzheimer’s Disease (AD). However, the causal association of this relationship remains unclear. To address th...
The burden of cerebral microbleeds (CMBs) is greater in patients with dementia with Lewy bodies (DLB) than in those with Parkinson disease dementia (PDD), while few studies have been carried out in a large sam...
Recurrent polychondritis is an immune-mediated systemic disease that affects cartilaginous and non-cartilaginous structures. Despite being rare, multiple neurological manifestations have been described, such a...
In advanced stages, Wallerian degeneration (WD) after cerebral infarction appears as an abnormality in the descending corticospinal tract on T2-weighted images. However, early WD in this region is detectable v...
A healthy lifestyle has been shown to mitigate cognitive decline in patients with mild cognitive impairment, with family caregivers playing a pivotal role in the patients’ lifestyle management. Exploring the l...
Parkinson’s disease (PD) is a complex neurodegenerative disorder with both motor and non-motor symptoms (NMS), the latter having a profound impact on patients’ quality of life (QoL). Increased recognition of N...
Miller-Fisher Syndrome (MFS), a distinct subtype of Guillain-Barré Syndrome (GBS), accounts for 5% of GBS cases and classically manifests with the triad of ophthalmoplegia, ataxia, and areflexia. Isolated bila...
Although there are a variety of risk factors and predictive models for stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS), the risk factors and predictive value for SAP in patients ...
Age-related diseases, including Parkinson’s disease and gastric cancer, substantially affect the global aging population. Previous observational research has suggested a potential association between Parkinson...
Polyneuritis cranialis (PNC), a rare variant of Guillain-Barré syndrome (GBS), is usually characterized by ocular and pharyngeal weakness without obvious numbness or weakness of the limbs or ataxia. Horner’s s...
Citation Impact 2023
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